John C. Flickinger, MD

  • Professor of Radiation Oncology
  • Physician, UPMC Presbyterian Gamma Knife and Shadyside Hospital

I have as strong interest in radiation treatment of brain tumors and in radiosurgery. I helped establish the first Gamma Knife radiosurgery center in the United States at UPMC Presbyterian in 1987 and have continued to direct the radiation oncology component of our Gamma Knife center there.

Teaching Activities

Teaching medical students and residents in their radiation oncology rotations

Representative Publications

Zwagerman NT, McDowell MM, Hamilton RL, Monaco EA 3rd, Flickinger JC, Gerszten PC. Histopathological examination of spine tumors after treatment with radiosurgery. Neurosurg Focus. 2016 Aug;41(2):E14. doi: 10.3171/2016.5.FOCUS16119.

Huang MJ, Kano H, Mousavi SH, Niranjan A, Monaco EA 3rd, Arai Y, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for recurrent vestibular schwannoma after previous resection. J Neurosurg. 2016 Jul 29:1-8. [Epub ahead of print]

Mousavi SH, Akpinar B, Niranjan A, Agarwal V, Cohen J, Flickinger JC, Kondziolka D, Lunsford LD. The clinical significance of persistent trigeminal nerve contrast enhancement in patients who undergo repeat radiosurgery. J Neurosurg. 2016 Jul 29:1-7. [Epub ahead of print]

Hashmi A, Guckenberger M, Kersh R, Gerszten PC, Mantel F, Grills IS, Flickinger JC, Shin JH, Fahim DK, Winey B, Oh K, John Cho BC, Létourneau D, Sheehan J, Sahgal A. Re-irradiation stereotactic body radiotherapy for spinal metastases: a multi-institutional outcome analysis. J Neurosurg Spine. 2016 Jun 24:1-8. [Epub ahead of print]

Toussaint A, Richter A, Mantel F, Flickinger JC, Grills IS, Tyagi N, Sahgal A, Letourneau D, Sheehan JP, Schlesinger DJ, Gerszten PC, Guckenberger M. Variability in spine radiosurgery treatment planning - results of an international multi-institutional study. Radiat Oncol. 2016 Apr 18;11:57. doi: 10.1186/s13014-016-0631-9.

Quan K, Xu KM, Zhang Y, Clump DA, Flickinger JC, Lalonde R, Burton SA, Heron DE. Toxicities Following Stereotactic Ablative Radiotherapy Treatment of Locally-Recurrent and Previously Irradiated Head and Neck Squamous Cell Carcinoma. Semin Radiat Oncol. 2016 Apr;26(2):112-9. doi: 10.1016/j.semradonc.2015.11.007. Epub 2015 Nov 27

Akpinar B, Mousavi SH, McDowell MM, Niranjan A, Faraji AH, Flickinger JC, Lunsford LD. Early Radiosurgery Improves Hearing Preservation in Vestibular Schwannoma Patients With Normal Hearing at the Time of Diagnosis. Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):729-34. doi: 10.1016/j.ijrobp.2016.01.019. Epub 2016 Jan 19.

Jawad MS, Fahim DK, Gerszten PC, Flickinger JC, Sahgal A, Grills IS, Sheehan J, Kersh R, Shin J, Oh K, Mantel F, Guckenberger M; , on behalf of the Elekta Spine Radiosurgery Research Consortium. Vertebral compression fractures after stereotactic body radiation therapy: a large, multi-institutional, multinational evaluation. J Neurosurg Spine. 2016 Jun;24(6):928-36. doi:

10.3171/2015.10.SPINE141261. Epub 2016 Feb 19.

Mousavi SH, Niranjan A, Akpinar B, Huang M, Kano H, Tonetti D, Flickinger JC,  Dade Lunsford L. Hearing subclassification may predict long-term auditory outcomes after radiosurgery for vestibular schwannoma patients with good hearing. J Neurosurg. 2016 Jan 8:1-8. [Epub ahead of print]

Mousavi SH, Niranjan A, Huang MJ, Laghari FJ, Shin SS, Mindlin JL, Flickinger JC, Lunsford LD. Early radiosurgery provides superior pain relief for trigeminal  neuralgia patients. Neurology. 2015 Dec 15;85(24):2159-65. doi: 10.1212/WNL.0000000000002216. Epub 2015 Nov 11.

Chapman BV, Rajagopalan MS, Heron DE, Flickinger JC, Beriwal S. Clinical Pathways: A Catalyst for the Adoption of Hypofractionation for Early-Stage Breast Cancer. Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):854-61. doi: 10.1016/j.ijrobp.2015.08.013. Epub 2015 Aug 7.

Gebhardt BJ, Rajagopalan MS, Gill BS, Heron DE, Rakfal SM, Flickinger JC, Beriwal S. Impact of dynamic changes to a bone metastases pathway in a large, integrated, National Cancer Institute-designated comprehensive cancer center network. Pract Radiat Oncol. 2015 Nov-Dec;5(6):398-405. doi: 10.1016/j.prro.2015.06.013. Epub 2015 Jul 4.

Gill BS, Flickinger JC, Beriwal S. Caveat for Immortal Time Bias in Adjuvant  Therapy-Related Population-Based Analyses. J Clin Oncol. 2015 Sep 10;33(26):2931. doi: 10.1200/JCO.2015.62.3306. Epub 2015 Jul 27.

Harrison G, Kano H, Lunsford LD, Flickinger JC, Kondziolka D. Quantitative tumor volumetric responses after Gamma Knife radiosurgery for meningiomas. J Neurosurg. 2016 Jan;124(1):146-54. doi: 10.3171/2014.12.JNS141341. Epub 2015 Jul  10.

Rajagopalan MS, Flickinger JC, Heron DE, Beriwal S. Changing practice patterns for breast cancer radiation therapy with clinical pathways: An analysis  of hypofractionation in a large, integrated cancer center network. Pract Radiat Oncol. 2015 Mar-Apr;5(2):63-9. doi: 10.1016/j.prro.2014.10.004.

Mousavi SH, Kano H, Faraji AH, Gande A, Flickinger JC, Niranjan A, Monaco E 3rd, Lunsford LD. Hearing preservation up to 3 years after gamma knife radiosurgery for Gardner-Robertson class I patients with vestibular Schwannomas.  Neurosurgery. 2015 May;76(5):584-90; discussion 590-1. doi: 10.1227/NEU.0000000000000674.

Niranjan A, Kano H, Iyer A, Kondziolka D, Flickinger JC, Lunsford LD. Role of adjuvant or salvage radiosurgery in the management of unresected residual or progressive glioblastoma multiforme in the pre-bevacizumab era. J Neurosurg. 2015 Apr;122(4):757-65. doi: 10.3171/2014.11.JNS13295. Epub 2015 Jan 16.

Ling DC, Vargo JA, Wegner RE, Flickinger JC, Burton SA, Engh J, Amankulor N,  Quinn AE, Ozhasoglu C, Heron DE. Postoperative stereotactic radiosurgery to the resection cavity for large brain metastases: clinical outcomes, predictors of intracranial failure, and implications for optimal patient selection. Neurosurgery. 2015 Feb;76(2):150-6; discussion 156-7; quiz 157. doi: 10.1227/NEU.0000000000000584.

Tonetti D, Kano H, Bowden G, Flickinger JC, Lunsford LD. Hemorrhage during pregnancy in the latency interval after stereotactic radiosurgery for arteriovenous malformations. J Neurosurg. 2014 Dec;121 Suppl:226-31. doi: 10.3171/2014.7.GKS141297.

Guckenberger M, Mantel F, Gerszten PC, Flickinger JC, Sahgal A, Létourneau D, Grills IS, Jawad M, Fahim DK, Shin JH, Winey B, Sheehan J, Kersh R. Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis. Radiat Oncol. 2014 Oct 16;9:226. doi: 10.1186/s13014-014-0226-2.

Park SH, Kano H, Niranjan A, Monaco E 3rd, Flickinger JC, Lunsford LD. Gamma  Knife radiosurgery for meningiomas arising from the tentorium: a 22-year experience. J Neurooncol. 2015 Jan;121(1):129-34. doi: 10.1007/s11060-014-1605-0. Epub 2014 Sep 4.

Iyer A, Harrison G, Kano H, Weiner GM, Luther N, Niranjan A, Flickinger JC,Lunsford LD, Kondziolka D. Volumetric response to radiosurgery for brain metastasis varies by cell of origin. J Neurosurg. 2014 Sep;121(3):564-9. doi: 10.3171/2014.4.JNS131502. Epub 2014 May 30.

Kondziolka D, Patel AD, Kano H, Flickinger JC, Lunsford LD. Long-term Outcomes After Gamma Knife Radiosurgery for Meningiomas. Am J Clin Oncol. 2014 Apr 21. [Epub ahead of print].

24: Varlotto JM, Decamp MM, Flickinger JC, Lake J, Recht A, Belani CP, Reed MF, Toth JW, Mackley HB, Sciamanna CN, Lipton A, Ali SM, Mahraj RP, Gilbert CR, Yao N. Would screening for lung cancer benefit 75- to 84-year-old residents of the United States? Front Oncol. 2014 Mar 7;4:37. doi: 10.3389/fonc.2014.00037. eCollection 2014.

Kano H, Flickinger JC, Yang HC, Flannery TJ, Tonetti D, Niranjan A, Lunsford  LD. Stereotactic radiosurgery for Spetzler-Martin Grade III arteriovenous malformations. J Neurosurg. 2014 Apr;120(4):973-81. doi: 10.3171/2013.12.JNS131600. Epub 2014 Jan 31.

Gande A, Kano H, Bowden G, Mousavi SH, Niranjan A, Flickinger JC, Lunsford LD. Gamma Knife radiosurgery of olfactory groove meningiomas provides a method to preserve subjective olfactory function. J Neurooncol. 2014 Feb;116(3):577-83. doi: 10.1007/s11060-013-1335-8. Epub 2014 Jan 8.

Park SH, Kano H, Niranjan A, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for cerebellopontine angle meningiomas. J Neurosurg. 2014 Mar;120(3):708-15. doi: 10.3171/2013.11.JNS131607. Epub 2013 Dec 13.

Kondziolka D, Parry PV, Lunsford LD, Kano H, Flickinger JC, Rakfal S, Arai Y, Loeffler JS, Rush S, Knisely JP, Sheehan J, Friedman W, Tarhini AA, Francis L, Lieberman F, Ahluwalia MS, Linskey ME, McDermott M, Sperduto P, Stupp R. The accuracy of predicting survival in individual patients with cancer. J Neurosurg.  2014 Jan;120(1):24-30. doi: 10.3171/2013.9.JNS13788. Epub 2013 Oct 25.